Universitätsklinikum Hamburg-eppendorf
نویسندگان
چکیده
Background: Aberrant salience in schizophrenia is mainly attributed to excessive dopaminergic reward processing in the ventral striatum (Kapur 2003). In addition, a recent study investigating early sensory processing indicated that increased gamma power evoked by physically-salient stimuli is associated with positive trait schizotypy (Kornmayer et al. 2015). Accordingly, the present study was intended to investigate early processing of physically salient stimuli in patients with schizophrenia. Methods: The early evoked visual gamma-band response at 40Hz (GBR) was assessed for a schizophrenia patient group (N = 22) and a matched healthy control group (N = 22) applying EEG time-frequency analysis. The evoked GBR was assessed for two conditions within a visual detection paradigm: a non salient target-only condition and a physically-salient distracter condition. GBR power was assessed for both groups and conditions and evaluated in relation to five dimensions of the PANSS symptom score (Van der Gaag, 2006). Results: A 2 x 2 ANOVA revealed a significant interaction of group and condition for the early visual GBR, with highest power for schizophrenia patients in the physically-salient distracter condition. Moreover, evoked GBR power in this condition was correlated with positive (r =.738; p < .0001**) and disorganized (r = .690; p < .0001**) schizophrenia symptoms. Conclusions: An increase of evoked GBR power during processing of physical salience in schizophrenia was associated with more positive symptoms. We suggest that abnormal processing of physically-salient stimuli might be involved in the pathophysiological genesis of positive symptoms.
منابع مشابه
Universitätsklinikum Hamburg-eppendorf
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